Upstream Processing

A Q&A with Alan Shaw of Vaxinnate. This article is part of a special section on expression systems.

Industry experts discuss the benefits and challenges of self-administration of injectable therapies.

A technical rountable featuring Sartorius Stedim Biotech, Pall Life Sciences, 3M Purification, Asahi Kasei Bioprocess, and Bio-Rad Laboratories.

The authors describe a new assembly for bulk and final drug product filling operations.

BioPharm talks with Tarja Mottram, CEO of Action for Results, about key business considerations when starting out.

Demonstration of large-scale stem-cell scale-up.

Recombinant albumin can stabilize a drug product and assist in API release.

Key technical considerations when developing a clinical project in the biotech world.

This month, we revisit "Industrial-Scale Mammalian Cell Culture, Part I: Bioreactor Design Considerations."

Recombinant technology can be used to produce conjugate vaccines.

Readers react to the economic turmoil of the past year and look longingly forward to 2012.

New technology is designed to improve production efficiency by taking advantage of the properties of single-use bags.

Biosimilar manufacturers need better expression systems and analytical tools to compete.

Despite their difficult approval pathway, biobetters offer the potential for innovation and decreased healthcare costs.

An evaluation of the technologies needed to develop a safe, effective, and economically efficient vaccine. This article is part of a special section on vaccines.

Development of the ideal DNA vaccine requires the optimization of delivery strategies and plasmid vectors.

A survey provides insight into drug companies' plans for spending on outsourced services. This article contains bonus online material.

The authors provide insight into microRNA biology, and the simplicity of anti-miR oligonucleotide drug delivery.

How to strike a balance between site autonomy and global coordination.

The authors describe challenges faced in transfer and scale-up of a fermentation process.

Cell concentrations and resulting protein concentrations are higher in a concentrated fed-batch process than in a standard fed-batch culture system.

A recent industry survey shows keen interest in improving bioreactors and cell-culture media.

An off-the-shelf, single-use perfusion system.

An overview of applications in the analysis of nutrients and metabolites.

A plant-based expression system could provide greater speed and capacity at a comparatively low cost.

A hollow fiber matrix allows for efficient harvest of secreted proteins.

The authors discuss an alternative to traditional Protein A resins.

The authors developed a test for defects in filter membranes.

The authors examine several issues that will help streamline negotiations between a service provider and a cell-culture medium consumer.

The authors present lessons learned from a case study of the transfer of a cell culture biotherapeutic process to a CMO.