Downstream Processing

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Advantages of Single-Use Chromatography Systems for Downstream Processing

By Cynthia A. Challener

March 8th 2025

The benefits include reduced contamination risks, simplified validation processes, and streamlined operations.

Growing Bacteria in Petri Dishes on agar gel Scientific experiment. | Image Credit: ©luchschenF- Stock.Adobe.com

Overcoming Viral Clearance Challenges

By Cynthia A. Challener

December 5th 2024

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Advances in Filtration Technology

By Cynthia A. Challener

September 7th 2024

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Automation Downstream Controls Quality

By Susan Haigney

August 21st 2024

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Streamlining Bioprocesses with Automation

By Susan Haigney

August 9th 2024

Fouling Mechanisms of Filters in the Harvest Development of Monoclonal Antibody Therapeutics—Pt 2

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

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Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2; Image: Dr_Microbe - stock.adobe.com

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Life Sciences – Sterile Filtration: Filter Sizing for Process Optimization

Entegris

November 20th 2024

Webinar Date/Time: Thu, Dec 12, 2024 11:00 AM EST

Advancing core workflows with the Intabio ZT system

SCIEX

October 18th 2024

Webinar Date/Time: Thu, Nov 7, 2024 11:00 AM EDT

Accelerating High-Titer Expression for Complex Next-Gen Biologics

Catalent

October 2nd 2024

Webinar Date/Time: Thu, Oct 31, 2024 11:00 AM EDT

Oral Lipid-Based Formulations: Unlocking Value in Early-Stage Pharmaceutical Development

Catalent

September 27th 2024

Webinar Date/Time: Wed, Oct 16, 2024 11:00 AM EDT

Robust Oligonucleotide Molecular Weight Confirmation by LC-MS

Agilent

September 24th 2024

Webinar Date/Time: Tue, Oct 8, 2024 11:00 AM EDT

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Freudenberg Adds Custom Single-Use Assemblies to Biopharma Product Portfolio

Feliza Mirasol

August 5th 2024

Freudenberg Medical now offers custom single-use assemblies to expand its offerings in silicone extrusion and molding for biopharma applications.

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

SCIEX

July 1st 2024

Webinar Date/Time: Wed, Jul 24, 2024 12:00 PM EDT

Ecolab Life Sciences and Repligen Launch New Affinity Resin for Commercial Biologics Manufacturing

Feliza Mirasol

June 13th 2024

Ecolab Life Sciences and Repligen introduce DurA Cycle, a new affinity resin for large-scale biologics manufacturing.

Binary pump in HPLC system. High performance liquid chromatography at analytical chemistry laboratory. | Image Credit: © vladim_ka - © vladim_ka - stock.adobe.com

Evaluating the Use of Continuous Chromatography

Feliza Mirasol

June 8th 2024

The biopharma industry is looking at continuous chromatography for sensitive molecules.

Achieve Scalable and High Recovery in rAAV Harvest Process

Avantor, Inc.

May 30th 2024

Webinar Date/Time: Wed, Jun 19, 2024 11:00 AM EDT

USP Standards to Support the Characterization of mAbs: Applications and General Chapter 129

USP

May 16th 2024

Webinar Date/Time: Thu, Jun 13, 2024 11:00 AM EDT

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HIC Demonstrates Promising Separation of Deaminated and Non-Deaminated AAV Capsids (ASGCT 2024)

Feliza Mirasol

May 10th 2024

Studies conducted by a team at Oxford Biomedica demonstrated that HIC can be used to effectively separate non-deamidated capsids from deamidated capsids.

Additives Play a Role in Removal of Empty and Partial AAV Capsids (ASGCT 2024)

Feliza Mirasol

May 8th 2024

Experiments conducted by the downstream technology team at Spark Therapeutics involving metal ion-containing additives showed improved capsid clearance in AAV production.

Viral Safety of Cell Banks: Replacing Animal-Based Assays by One Single GMP Transcriptomic Test

PathoQuest

April 22nd 2024

Webinar Date/Time: Tue, May 14, 2024 1:00 PM EDT

Sartorius In-Line Lysis System: The Easiest Alternative to Batch Alkaline Lysis

Sartorius

April 22nd 2024

Webinar Date/Time: Tue, Jun 11, 2024 10:00 AM EDT

What bottleneck? New strategies for a better glycosylation profile

SCIEX

April 19th 2024

Webinar Date/Time: Tue, May 21, 2024 11:00 AM EDT

Viral Clearance in the Age of Q5A(R2) and the Case for Utilizing Non-Infectious Spiking Agents

Cygnus Technologies

April 17th 2024

Webinar Date/Time: Thu, May 16, 2024 11:00 AM EDT

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Benefiting from Single-Use Tech Downstream

Cynthia A. Challener

April 2nd 2024

Increases in efficiencies, flexibility, scalability, and sustainability are impacting adoption.

Graphene water filter, 3D illustration | Image Credit: © Dr_Microbe - stock.adobe.com; doctor analyzes monoclonal antibodies | Image Credit: © Paulista - stock.adobe.com; Final image by Maria Xelo

A Closer Look at Affinity Ligands

Daria G. Husni

April 1st 2024

A look at the newest innovations offers a deeper understanding of affinity ligands and their role in the future of downstream processing.

Transforming Process Development with AI: Success Stories from mAbs to Emerging Modalities

DataHow

March 25th 2024

Webinar Date/Time: Thu, Thu, Apr 18, 2024 11:00 AM EDT

UpTempoSM Antibody: A Streamlined Platform Process to Accelerate Biotherapeutics from Gene to Clinic

Catalent

March 21st 2024

Webinar Date/Time: Wed, May 8, 2024 11:00 AM EDT

Molecular model of antibody taking part in immune defense. Molecule of immunoglobulin, 3D illustration | Image Credit: © Dr_Microbe - Stock.Adobe.com

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2

Stijn H. S. Koshari ;Hong Zhang;Antonio Ubiera;Robert G. Luo

March 2nd 2024

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

Expediting the Delivery of Your Innovative Biologics to the Clinic and Beyond

WuXi Biologics

February 21st 2024

Webinar Date/Time: Wed, Mar 20, 2024 11:00 AM EDT

In Pursuit of High Concentration Protein Formulations

Curia

February 16th 2024

Webinar Date/Time: Thu, Mar 21, 2024 11:00 AM EDT

Purolite and Repligen Launch New Affinity Resin

Feliza Mirasol

February 7th 2024

Purolite and Repligen have commercially launched a new CH1 affinity resin for the purification of specialized mAbs.

A monoclonal antibody (mAb or moAb) is an antibody made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Coronavirus. 3d render| ©Naeblys - stock.adobe.com

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 1

Stijn H. S. Koshari ;Hong Zhang;Antonio Ubiera;Robert G. Luo

February 2nd 2024

The authors present a methodology to assess the contribution of individual filters to overall capacity of the direct filtration train, and elucidate how capacity is affected by characteristics of the cell culture broth and process parameters, including for enhanced upstream processes such as those incorporating high cell density perfusion.