Downstream Processing

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Automation Advances for Cell Harvesting in Biomanufacturing

May 6th 2025

Although automation is increasingly adopted in biomanufacturing, challenges remain in implementing it at the cell harvesting step.

Young researcher working with chemical samples in laboratory with HPLC system and chromatography equipment | Image Credit: © BGStock72 – Stock.Adobe.com
Advantages of Single-Use Chromatography Systems for Downstream Processing

March 8th 2025

Growing Bacteria in Petri Dishes on agar gel Scientific experiment. | Image Credit: ©luchschenF- Stock.Adobe.com
Overcoming Viral Clearance Challenges

December 5th 2024

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Advances in Filtration Technology

September 7th 2024

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Automation Downstream Controls Quality

August 21st 2024

Fouling Mechanisms of Filters in the Harvest Development of Monoclonal Antibody Therapeutics—Pt 2

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2; Image: Dr_Microbe - stock.adobe.com
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Mastering SEC Biotherapeutic Characterization and Method Development

Mastering SEC Biotherapeutic Characterization and Method Development

Phenomenex
April 29th 2025

Webinar Date/Time: Tue, Jun 3, 2025 2:00 PM EDT

Particle risk mitigation in biomanufacturing

Particle risk mitigation in biomanufacturing

Entegris
April 25th 2025

Webinar Date/Time: Tue, May 20, 2025 2:00 PM EDT

Life Sciences – Sterile Filtration: Filter Sizing for Process Optimization

Life Sciences – Sterile Filtration: Filter Sizing for Process Optimization

Entegris
November 20th 2024

Webinar Date/Time: Thu, Dec 12, 2024 11:00 AM EST

Advancing core workflows with the Intabio ZT system

Advancing core workflows with the Intabio ZT system

SCIEX
October 18th 2024

Webinar Date/Time: Thu, Nov 7, 2024 11:00 AM EDT

Accelerating High-Titer Expression for Complex Next-Gen Biologics

Accelerating High-Titer Expression for Complex Next-Gen Biologics

Catalent
October 2nd 2024

Webinar Date/Time: Thu, Oct 31, 2024 11:00 AM EDT

Oral Lipid-Based Formulations: Unlocking Value in Early-Stage Pharmaceutical Development

Oral Lipid-Based Formulations: Unlocking Value in Early-Stage Pharmaceutical Development

Catalent
September 27th 2024

Webinar Date/Time: Wed, Oct 16, 2024 11:00 AM EDT

Robust Oligonucleotide Molecular Weight Confirmation by LC-MS

Robust Oligonucleotide Molecular Weight Confirmation by LC-MS

Agilent
September 24th 2024

Webinar Date/Time: Tue, Oct 8, 2024 11:00 AM EDT

Drug manufacturing process. Conveyor with medical ampoules line at a modern pharmaceutical plant. Pharmacology production, medicine industry from laboratory 2 factory, pharmacy. Healthcare, pharma 3D | Image Credit: ©Corona Borealis - stock.adobe.com

Streamlining Bioprocesses with Automation

Susan Haigney
August 9th 2024

Automation technologies used in the development and manufacture of biopharmaceuticals continue to evolve, providing the potential for reduced costs and time.

Communication between the manufacturing plant and retail stores. | Image Credit: © Cagkan - © Cagkan - stock.adobe.com

Freudenberg Adds Custom Single-Use Assemblies to Biopharma Product Portfolio

Feliza Mirasol
August 5th 2024

Freudenberg Medical now offers custom single-use assemblies to expand its offerings in silicone extrusion and molding for biopharma applications.

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

SCIEX
July 1st 2024

Webinar Date/Time: Wed, Jul 24, 2024 12:00 PM EDT

Communication between the manufacturing plant and retail stores. | Image Credit: © Cagkan - © Cagkan - stock.adobe.com

Ecolab Life Sciences and Repligen Launch New Affinity Resin for Commercial Biologics Manufacturing

Feliza Mirasol
June 13th 2024

Ecolab Life Sciences and Repligen introduce DurA Cycle, a new affinity resin for large-scale biologics manufacturing.

Binary pump in HPLC system. High performance liquid chromatography at analytical chemistry laboratory. | Image Credit: © vladim_ka - © vladim_ka - stock.adobe.com

Evaluating the Use of Continuous Chromatography

Feliza Mirasol
June 8th 2024

The biopharma industry is looking at continuous chromatography for sensitive molecules.

Achieve Scalable and High Recovery in rAAV Harvest Process

Achieve Scalable and High Recovery in rAAV Harvest Process

Avantor, Inc.
May 30th 2024

Webinar Date/Time: Wed, Jun 19, 2024 11:00 AM EDT

USP Standards to Support the Characterization of mAbs: Applications and General Chapter 129

USP Standards to Support the Characterization of mAbs: Applications and General Chapter 129

USP
May 16th 2024

Webinar Date/Time: Thu, Jun 13, 2024 11:00 AM EDT

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HIC Demonstrates Promising Separation of Deaminated and Non-Deaminated AAV Capsids (ASGCT 2024)

Feliza Mirasol
May 10th 2024

Studies conducted by a team at Oxford Biomedica demonstrated that HIC can be used to effectively separate non-deamidated capsids from deamidated capsids.

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Additives Play a Role in Removal of Empty and Partial AAV Capsids (ASGCT 2024)

Feliza Mirasol
May 8th 2024

Experiments conducted by the downstream technology team at Spark Therapeutics involving metal ion-containing additives showed improved capsid clearance in AAV production.

Viral Safety of Cell Banks: Replacing Animal-Based Assays by One Single GMP Transcriptomic Test

Viral Safety of Cell Banks: Replacing Animal-Based Assays by One Single GMP Transcriptomic Test

PathoQuest
April 22nd 2024

Webinar Date/Time: Tue, May 14, 2024 1:00 PM EDT

Sartorius In-Line Lysis System: The Easiest Alternative to Batch Alkaline Lysis.

Sartorius In-Line Lysis System: The Easiest Alternative to Batch Alkaline Lysis

Sartorius
April 22nd 2024

Webinar Date/Time: Tue, Jun 11, 2024 10:00 AM EDT

What bottleneck? New strategies for a better glycosylation profile

What bottleneck? New strategies for a better glycosylation profile

SCIEX
April 19th 2024

Webinar Date/Time: Tue, May 21, 2024 11:00 AM EDT

Viral Clearance in the Age of Q5A(R2) and the Case for Utilizing Non-Infectious Spiking Agents

Viral Clearance in the Age of Q5A(R2) and the Case for Utilizing Non-Infectious Spiking Agents

Cygnus Technologies
April 17th 2024

Webinar Date/Time: Thu, May 16, 2024 11:00 AM EDT

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Benefiting from Single-Use Tech Downstream

Cynthia A. Challener
April 2nd 2024

Increases in efficiencies, flexibility, scalability, and sustainability are impacting adoption.

Graphene water filter, 3D illustration | Image Credit: © Dr_Microbe - stock.adobe.com; doctor analyzes monoclonal antibodies | Image Credit: © Paulista - stock.adobe.com; Final image by Maria Xelo

A Closer Look at Affinity Ligands

Daria G. Husni
April 1st 2024

A look at the newest innovations offers a deeper understanding of affinity ligands and their role in the future of downstream processing.

Transforming Process Development with AI: Success Stories from mAbs to Emerging Modalities

Transforming Process Development with AI: Success Stories from mAbs to Emerging Modalities

DataHow
March 25th 2024

Webinar Date/Time: Thu, Thu, Apr 18, 2024 11:00 AM EDT

UpTempoSM Antibody: A Streamlined Platform Process to Accelerate Biotherapeutics from Gene to Clinic

UpTempoSM Antibody: A Streamlined Platform Process to Accelerate Biotherapeutics from Gene to Clinic

Catalent
March 21st 2024

Webinar Date/Time: Wed, May 8, 2024 11:00 AM EDT

Molecular model of antibody taking part in immune defense. Molecule of immunoglobulin, 3D illustration | Image Credit: © Dr_Microbe - Stock.Adobe.com

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2

Stijn H. S. Koshari ;Hong Zhang;Antonio Ubiera;Robert G. Luo
March 2nd 2024

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

Expediting the Delivery of Your Innovative Biologics to the Clinic and Beyond

Expediting the Delivery of Your Innovative Biologics to the Clinic and Beyond

WuXi Biologics
February 21st 2024

Webinar Date/Time: Wed, Mar 20, 2024 11:00 AM EDT

In Pursuit of High Concentration Protein Formulations

In Pursuit of High Concentration Protein Formulations

Curia
February 16th 2024

Webinar Date/Time: Thu, Mar 21, 2024 11:00 AM EDT

Communication between the manufacturing plant and retail stores. | Image Credit: © Cagkan - © Cagkan - stock.adobe.com

Purolite and Repligen Launch New Affinity Resin

Feliza Mirasol
February 7th 2024

Purolite and Repligen have commercially launched a new CH1 affinity resin for the purification of specialized mAbs.

A monoclonal antibody (mAb or moAb) is an antibody made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Coronavirus. 3d render| ©Naeblys - stock.adobe.com

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 1

Stijn H. S. Koshari ;Hong Zhang;Antonio Ubiera;Robert G. Luo
February 2nd 2024

The authors present a methodology to assess the contribution of individual filters to overall capacity of the direct filtration train, and elucidate how capacity is affected by characteristics of the cell culture broth and process parameters, including for enhanced upstream processes such as those incorporating high cell density perfusion.

A man in protective clothing with test tubes in his hands against the background of a laboratory bioreactor.Experiments in the field of Microbiology. Pharmaceutical research.Synthesis of new chemicals | Image credit: © Grispb - stock.adobe.com

Stepping Up Process Control with Single-Use Systems

Chris Spivey
February 2nd 2024

SUS aids biopharma manufacturers to overcome the rigidity of more traditional stainless-steel technologies.

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