Manufacturing

Feliza Mirasol is the science editor for 

Articles

Lonza’s Synnafix has licensed its ADC technology to BigHat Biosciences, which will combine it with its ML design platform to generate newly designed ADCs.

Lonza’s Synaffix and BigHat Biosciences Team Up on Machine Learning-Designed ADCs

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

The best strategy is to use a combination of complementary methods.

Glycosylation Analysis for Multispecifics

Syngene has launched a new protein production platform that offers faster production with lower risk.

Syngene Launches Rapid Protein Synthesis Platform

Lonza has made a deal with Acumen Pharmaceuticals to manufacture sabirnetug, a mAb that will soon be entering Phase II development for treating Alzheimer’s disease.

Lonza Set to Manufacture Acumen Pharmaceuticals’ mAb for Alzheimer’s Disease

ProBioGen and Mapp Biopharmaceutical will use the former’s GlymaxX technology to develop a cell line for an afucosylated antibody that targets Marburg virus infection

ProBioGen and Mapp Biopharmaceutical Partner to Develop Antibody Against Marburg Virus Disease

Stijn H. S. Koshari is a principal investigator at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Hong Zhang is an investigator at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Antonio Ubiera is a senior director at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Robert G. Luo is a scientific director, at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2

Under the new partnership, Samsung Biologics will develop and manufacture an antibody for a LegoChem Biosciences ADC candidate.

Samsung Biologics Partners with LegoChem Biosciences on ADCs 

Purolite and Repligen have commercially launched a new CH1 affinity resin for the purification of specialized mAbs.

Purolite and Repligen Launch New Affinity Resin

The authors present a methodology to assess the contribution of individual filters to overall capacity of the direct filtration train, and elucidate how capacity is affected by characteristics of the cell culture broth and process parameters, including for enhanced upstream processes such as those incorporating high cell density perfusion. 

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 1

Abzena has launched its AbZelect platforms, designed for improving cell line development.

Manufacturing, Monoclonal Antibodies