Downstream Processing

Feliza Mirasol is the science editor for 

Articles

Ecolab Life Sciences and Repligen introduce DurA Cycle, a new affinity resin for large-scale biologics manufacturing.

Ecolab Life Sciences and Repligen Launch New Affinity Resin for Commercial Biologics Manufacturing

The biopharma industry is looking at continuous chromatography for sensitive molecules.

Evaluating the Use of Continuous Chromatography

Studies conducted by a team at Oxford Biomedica demonstrated that HIC can be used to effectively separate non-deamidated capsids from deamidated capsids.

HIC Demonstrates Promising Separation of Deaminated and Non-Deaminated AAV Capsids (ASGCT 2024)

Experiments conducted by the downstream technology team at Spark Therapeutics involving metal ion-containing additives showed improved capsid clearance in AAV production.

Additives Play a Role in Removal of Empty and Partial AAV Capsids (ASGCT 2024)

Stijn H. S. Koshari is a principal investigator at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Hong Zhang is an investigator at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Antonio Ubiera is a senior director at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

Robert G. Luo is a scientific director, at Downstream Process Development, BioPharma R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406.

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2

Purolite and Repligen have commercially launched a new CH1 affinity resin for the purification of specialized mAbs.

Purolite and Repligen Launch New Affinity Resin

The authors present a methodology to assess the contribution of individual filters to overall capacity of the direct filtration train, and elucidate how capacity is affected by characteristics of the cell culture broth and process parameters, including for enhanced upstream processes such as those incorporating high cell density perfusion. 

Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 1

The 3M Harvest RC Chromatographic Clarifier, BT500 is the latest addition to the company’s chromatographic clarifier portfolio.

3M Health Care Launches New Chromatographic Clarifier

Chris Spivey is the editorial director of 

USP offers strategies to minimize residual impurities in downstream processing.

Paring Down Impurities in Downstream Processing

The innovation of affinity ligands must take stability into consideration for present and future purification applications.

Manufacturing, Separation and Purification