Manufacturing, Recombinant Proteins

Aragen Bioscience has licensed ProteoNic Biotechnology’s 2G UNic recombinant protein production technology, which increases manufacturing efficiency and reduces cost of goods for recombinant biologicals.

The correlation between limulus amebocyte lysate (LAL) assay and rabbit pyrogen test (RPT) targeting recombinant human epidermal growth factor (rhEGF) as active molecule was assessed.

Industry experts discuss significant achievements. Plus: What's in store for the future.

Simple methods can characterize polysaccharide vaccines and recombinant cytokines at high resolution.

Salt-tolerant adsorption and unique selectivity are the major advantages of mixed-mode materials over single-mode resins.

Recombinant vector technologies can improve the yield and lower the cost of egg-based influenza vaccine production.

Method for integration of transgenes.

The year 2007 witnessed the approval of fifteen biopharmaceuticals in the United States and European Union.

With a variety of recombinant, animal-free, defined protein supplements such as growth factors, transferrin, and albumin entering the market, the biopharmaceutical industry now has innovative and safer alternatives to serum and other animal-derived supplements.

The current overcapacity situation in the bio/pharmaceutical industry is a reminder that CMOs need to come up with business models and value propositions that are based on more than just selling capacity.

Genentech has been notified that their Cabilly patent claim has been rejected by the US Patent and Trademark Office.

The biopharmaceutical industry has gained a lot of experience in monitoring glycosylation, but still has a lot to learn about the structure–function relationship.

The United States Pharmacopeia (USP, Rockville, MD, www.usp.org) and the UK's National Institute for Biological Standards and Control (NIBSC, Hertfordshire, UK, www.nibsc.ac.uk) are seeking participants in a study of analytical methods used by the industry to characterize and quantify oligosaccharides.

The type of reactive moiety controls the site and stability of the covalent link and also the total number of PEGylation sites on a given protein.