UPLC System for Nano- to Microscale Separations

Waters’ Acquity UPLC M-Class System, a nano- to microscale UPLC system rated for 15,000 psi operation, delivers the sensitivity to quantify and identify small concentrations of key molecules. The system is suited for applications including proteomics, metabolic profiling, metabolite identification, and pharmacokinetic studies. The 15k psi-capable Acquity UPLC M-Class columns tap the potential of sub-2-micron particle technology, yielding faster separations, greater peak capacities, and increased levels of sensitivity, the company reports.

A new micro electrospray ionization probe is optimized for microscale separations, along with low-dispersion flow cells that retain chromatographic resolution into the detector. The increased pressure envelope enables the Acquity UPLC M-Class System to exploit fully sub-2-micron particles in longer columns, up to 25 cm in length. The ACQUITY UPLC M-Class System, together with Waters SYNAPT G2-Si or Xevo G2-S QT mass spectrometers, delivers the spectral data required to resolve the small mass changes typical in hydrogen deuterium exchange mass spectrometry.

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