Straightforward AAV manufacturing process scale up from bench-scale to 2000L STR

Discuss the development and challenges of a highly scalable adeno-associated virus (AAV) manufacturing platform

Register Free: https://www.biopharminternational.com/bp_w/2000L

Event Overview:

Recombinantly produced adeno-associated viruses (AAV) are the predominant viral vectors used for in vivo gene therapies owing to their relatively good safety, long term transgene expression, ability to infect a broad range of cells and ease in achieving high titers at small-scale. One of the main challenges in bringing AAV-based therapies to patients, is the ability to efficiently translate bench-scale processes to commercial
GMP manufacturing while meeting the high dosage requirements. In this context, Polyplus, Exothera and Alexion collaborated for the development of a highly scalable AAV manufacturing platform with a capacity ranging from 1L to 200L and 2000L.

Key Learning Objectives:

• Developing scalable transfection process with DOE (Design of Experiments)
• Scaling-up while maintaining consistent transfection complex growth for efficient delivery to cells

Who Should Attend:

• Viral vector manufacturers
• Viral vector sponsors
• Pharma
• Biotech

Speakers:

Daniel Koback
Bioprocess Applications Specialist
Polypus

Daniel Koback holds a master’s degree in biomedical engineering from Worcester Polytechnic Institute. After several years of hands-on experience as senior associate scientist in Upstream Process Development working with rAAV gene therapy, mAbs, and vaccines, he joined Polyplus in 2022 as a Bioprocess Application Specialist.

Emilie Gateau
Innovation Manager
Exothera

Emilie Gateau holds a Master of Biotechnology and Food Science. She has over 6 years of experience in bioprocess development, with expertise in Quality by design & design of experiments experience, cell line development, upstream process scale-up experience, and mammalian cell culture process development for viral vectors and recombinant protein.

Register Free: https://www.biopharminternational.com/bp_w/2000L