Bioprocess for Beginners: From Shaker to Bioreactor
• Using stirred-tank bioreactors for stem cell culture provides advantages. • Factors to consider include OTR, agitation speed, and impeller blades. • An eight-blade impeller can address challenges associated with scale-up.
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Glycan analysis provides key information on critical quality attributes that could affect stability, safety and efficacy of a protein therapeutic. Specific needs for understanding the glycosylation profiles change throughout the drug development process, but the requirement for high-resolution glycan information remains the same and is essential to help ensure product quality.
