Manufacturing Equipment, Biologics

The authors present a case study in which four single-use vessels were fitted to an existing bioreactor system.

In semiconductor manufacturing, for example, a thorough understanding of process variation allows companies to manufacture circuits with billions of transistors at high yields. These variations are translated into a set of design rules, which help ensure that designs will be manufactured successfully and meet safety and other regulatory requirements.

The authors conclude that miniature bioreactors can adequately predict the cell culture kinetics in scaled-up reactors using equal mixing times.

The Bothell, WA location will help the company reach its goal of expanding its global capacity by more than 30,000 liters.

Sartorius Stedim Biotech’s Sartoclear Dynamics is a clarification system designed to harvest mammalian cell cultures with high cell densities using single-use technology.

Meissner’s single-use biocontainer, FlexGro, is designed for use with rocker-style bioreactors.

This article presents first-hand perspectives from industry users to suppliers of single-use sensors.

Rentschler Biotechnologie launches 2000-L single-use bioreactor and announces additional expansion.

The new 2000-L bioreactor will double Rentschler’s single-use manufacturing capabilities.

As more biologic drugs come to market, manufacturers will require improved bioprocessing technologies.

The YSI Sitini Online Sampler draws fluids from a bioreactor and delivers the samples to an analyzer.

EMD Millipore and PharmaCell have entered into a collaboration to develop optimized large-scale expansion and harvest of HepaRG cells using bioreactor technology.

Project will optimize expansion and harvest of human cells in bioreactors.

The authors describe the growth characteristics of human mesenchymal stem cells cultured in a stirred-tank bioreactor.

A look at vaccine history, markets, manufacturing, and overcoming the scale-up dilemma.

A brief case study of a facility-fit analysis provides insight into how to adjust capacity when moving from clinical-to commercial-scale production.

The authors explain why Catalent decided to transition from stainless steel to single-use systems.

Scaling up stem-cell cultures requires careful consideration of the bioreactor design.

This article discusses the evaluation of a novel single-use fluidized bed centrifuge for harvesting of antibodies.

Industry wants more innovation, but can suppliers meet customers' needs?

The authors present a case study identifying a contaminant.

Comparing the economic feasibility of a typical glycosylated protein.

A case study to compare the performances of several types of mixing in disposable bags with stainless steel bioreactors.

Computational fluid dynamics can resolve performance problems.

Computational fluid dynamics is a powerful tool to optimize processes.

An algorithmic approach to fine tune facility design and predict capacity.

How to improve facility design and predict capacity.

In new disposables projects, it is critical that engineering, procurement, and operations groups work together early on to manage supply chain risk.

An analysis of current and upcoming industry challenges.

A discussion of past achievements and future expectations of recombinant protein production yields from mammalian cells.