Best Practices in HCP Assay Development and Integration of Advanced Orthogonal Methods
October 11th 2022Tuesday, October 11, 2022 at 11 AM EDT Learn about best practices in Host Cell Protein (HCP) assay development and qualification. Improve your understanding of the advanced orthogonal methods used to fully characterize HCPs in your process
Characterization of Biotherapeutic Beasts by Mass Spectrometry
September 29th 2022Thursday, September 29, 2022 at 7am PT | 10am ET | 4pm CET Novel methods have been developed and applied on Biotherapeutics Beasts in the half Megadalton to 3-4 MDa range to measure AAV Full:Empty genome ratio using charge detection mass spectrometry on the Q Exactive UHMR mass spectrometer with Direct Mass Technology mode.
Automated High Throughput SEC Native Mass Spectrometry for mAb Screening
September 22nd 2022Thursday, September 22nd, 2022 9:00am EDT|6:00am PDT|2:00pm BST|3:00pm CEST 2:00pm EDT|11:00am PDT|7:00pm BST|8:00pm CEST See how RapidFire automated size exclusion chromatography (SEC) combined with the power of ion mobility mass spectrometry (IM-MS) enables efficient biotherapeutic development.
Innovation Standardized – High Performance Surface Consumables for Bioseparation
September 20th 2022Tuesday, September 20, 2022 at 11 AM EST During chromatographic analysis of complex biotherapeutics, analytes may contain electron-rich functional groups, which have an affinity to metal surfaces and may cause issues such as poor peak shape. Join our webinar to learn how Waters addresses these challenges.
Industrializing High-Throughput Glycoproteomics Using AI for Clinical Use
April 26th 2022Aberrant glycosylation of proteins has been implicated in key steps of disease biology, including the hallmarks of cancer as well as inflammation cascades associated with autoimmunity and aging. InterVenn Biosciences harnesses the predictive powers of artificial intelligence combined with cutting edge mass spectrometry to discover clinically relevant biomarkers that can only be revealed by high-resolution analysis of the glycoproteome.
Oligonucleotide Purification and Characterization - Tips for Success
March 30th 2022Wednesday, March 30th, 2022 at 11am SST | 2pm AEDT | 10am ICT | 12pm KST Applying the appropriate tools for oligonucleotide purification and subsequent analysis is a unique challenge requiring application specific solutions. Join Drs. Anne Blackwell and Matthew L. Turner of Agilent Technologies for tips on oligonucleotide analysis and purification with Agilent’s suite of Bio LC solutions.
Glycomics/Glycoproteomics for Biopharmaceutical and Biotechnology Industries
March 16th 2022Wednesday, March 16th, 2022 at 11am SST | 2pm AEDT | 10am ICT | 12pm KST Please join us for a series of three intense investigations into the practicalities required to define, identify, and explore the functions of important biological molecules including glycans, monoclonal antibodies, and oligonucleotides. We outline cutting edge and mainstay analytic tools and protocols, with multiple case studies and practical examples from world leading experts.
Laying the Foundation for Smart Manufacturing While Solving Today’s Tough Challenges On Demand
February 28th 2022Monday, February, 28, 2022 at 9am EST | 8am CST | 6am PST Realizing benefits from Smart Manufacturing technologies doesn’t have to be long-term prospect. Solve today’s manufacturing challenges while laying the foundation for tomorrow’s plant.
Rapid Analysis of mRNA 5’ Capping and Poly-A Tailing with High-Resolution LC-MS
January 11th 2022Tuesday, January, 11th, 2022 at 9am EST | 3pm CET | 2pm GMT Tuesday, January, 11th, 2022 at 2pm EST | 11am PST | 7pm GMToin us in our expert discussion of Rapid Analysis of mRNA 5’ Capping and Poly-A Tailing with High-Resolution LC-MS. See how mRNA capping can be analyzed by LC-MS within 75 minutes!
Moving SWATH LC–MS Host Cell Protein Analysis into a GMP Environment?
October 6th 2021Wednesday, October 6, 2021 at 12pm EDT | 9am PDT | 5pm BST | 6pm CEST In this webinar, you will learn about the possibility of GMP method transfer for HCP assays leveraging a robust and automated workflow based on combining data-dependent and data-independent mass spectrometry. A study of data from multiple projects over three years demonstrated the robustness and reproducibility of the method.
Increasing Upstream Bioprocessing Efficiency through Process Analytical Technology
September 29th 2021Wednesday, September 29, 2021 at 10am EDT| 7am PDT| 3pm BST| 4pm CEST Learn about strategies for inline process analytics aimed at automated feed control in an upstream bioprocess. Using the example of a Raman analyzer, a glucose analyzer, and an exhaust analyzer experts demonstrate how to achieve seamless sensor integration with the bioprocess control software.
Method Development Strategies for Purity Analysis of Proteins by Intact and Subunit Analysis
May 24th 2021***Live: Monday, May 24, 2021 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST *** Join us to learn best practices in method development for intact and subunit purity analysis for mAbs by reversed-phase liquid chromatography (RPLC), including how to best adjust method parameters such as temperature, gradient slope, and flow rate to obtain high-quality impurity profiling and ensure method robustness and reproducibility. ***On Demand until May 24, 2022***
Ultra-fast Analysis of Intact Proteins and Oligonucleotides Using High-Throughput Mass Spectrometry
April 26th 2021***Live: Monday, April 26, 2021 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST *** Analytical characterization of biomolecules can be challenging because impurities from the synthesis, expression, and degradation of the intended product make the samples complex. Discover the latest innovations, using high-throughput mass spectrometry, to streamline workflows, and simplify complicated analysis, increase throughput, and accelerate bringing biomolecules to market.***On Demand until Apr. 26, 2022***
Profiling the HLA-II Immunopeptidome of SARS-CoV-2 Spike Glycoprotein Using Mass Spectrometry.
March 30th 2021***Available Now!*** In this webinar, Mike Knierman, Eli Lilly, will discuss the use of mass spectrometry to identify unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from healthy donors. This work exemplifies the value-add of mass spectrometry in vaccine development. *On Demand until March 30, 2022*
A Material Characterization Study for AAV Process Development and Tool Selection
March 17th 2021***Live: Wednesday March 17, 2021 at 11am EDT| 8am PDT| 4pm GMT| 5pm CET *** Single-use material selection is a crucial element of process development for bioprocessing, and emerging viral vector-based therapies have special requirements. Learn about efforts to better understand the relationship of single-use material selection and process impact to improve yield. ***On Demand until March 17, 2022***
The Ever-Changing World of Extractables and Leachables, Part 2 A Free Virtual Conference
February 24th 2021***Live: Wednesday, February 24, 2021 at 10am EST | 3pm GMT | 4pm CET*** Join global industry and regulatory experts as they discuss current E&L hot topics related to pharmaceuticals, biopharmaceuticals and medical devices. ***On demand available after final airing until Feb. 24, 2022***
Quantitative LC–MS Workflow for Cell Culture Media Monitoring
January 20th 2021***Live: Wednesday, January 20, 2021 at 11am EST | 8am PST | 4 pm GMT | 5pm CET *** Cell culture media (CCM) optimization is a critical step during the development and scale up of biotherapeutic manufacturing process. In particular, the emphasis on quality by design has made it necessary to understand how the components of CCM change during production and how these changes relate to product quality. In this webcast, learn how targeted cell-culture media workflow can help scientists understand growth media for biotherapeutics and improve their manufacturing process. ***On demand available after final airing until Jan. 20, 2022***