Aligning mRNA Progress With Regulatory Streamlining - Episode 6

Overcoming Delivery Challenges of mRNA Therapeutics

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The key to advancing mRNA therapeutics lies in developing more efficient and versatile delivery systems that can overcome challenges around stability, targeting, and safety.

EP. 1: The Benefits of Working with mRNA for Therapeutics
EP. 2: Public Perception and Communicating the Potential and Safety of mRNA
EP. 3: Lessons from Vaccine Development and Future Possibilities
EP. 4: Streamlining Rare Disease Drug Development
EP. 5: Navigating Challenges and Embracing Opportunities to Optimize mRNA Therapies
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EP. 6: Overcoming Delivery Challenges of mRNA Therapeutics
EP. 7: The Future of Manufacturing, Safety, and Collaboration

This discussion segment centered around the need for improved mRNA delivery systems to advance therapeutics. Experts spoke about the importance of developing efficient and versatile delivery systems, such as LNPs, to target mRNA molecules to specific cell types or tissues. They also highlighted the need for delivery systems that can overcome shelf life or storage conditions, minimize adverse immune responses, and utilize self-amplifying mRNA delivery systems. The consensus was that delivery is the key to unlocking the full potential of mRNA therapeutics.

Discussion Topics

  • 00:07 - Identifying key advances needed to move the mRNA therapeutics field forward
  • 01:18 - Importance of developing efficient and versatile mRNA delivery systems
  • 01:49 - Overcoming mRNA product storage and shelf life limitations
  • 04:35 - Challenges and opportunities with LNP-based mRNA delivery, especially for solid organs