Authors
Latest:
Use of an E. coli pgi Knockout Strain as a Plasmid ProducerThe authors describe the impact of the knocking of the pgi gene of the wild type MG1655 strain on the growth kinetics of plasmid-free and plasmid-bearing cells.
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Use of an E. coli pgi Knockout Strain as a Plasmid ProducerThe authors describe the impact of the knocking of the pgi gene of the wild type MG1655 strain on the growth kinetics of plasmid-free and plasmid-bearing cells.
Latest:
Use of an E. coli pgi Knockout Strain as a Plasmid ProducerThe authors describe the impact of the knocking of the pgi gene of the wild type MG1655 strain on the growth kinetics of plasmid-free and plasmid-bearing cells.
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An Economic Analysis of Single-Use Tangential Flow Filtration for Biopharmaceutical ApplicationsSingle-use TFF offers the greatest savings in clinical and contract manufacturing, where the scale is low and changeovers are frequent.
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial ApplicationsThe authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial ApplicationsThe authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment ChallengeThe necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment ChallengeThe necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
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An Integrated Approach to Ensure the Viral Safety of BiotherapeuticsTesting product and process intermediates alone is helpful, but does not provide a complete solution to viral safety. This article proposes integrated solutions for systemic and proactive viral risk mitigation.
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Continuous Processing for the Production of BiopharmaceuticalsThe authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platforms.
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Continuous Processing for the Production of BiopharmaceuticalsThe authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platforms.
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A Coiled Flow Inversion Reactor Enables Continuous ProcessingA novel coiled flow inversion reactor (CFIR) improves process productivity and performance.
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Nontuberculosis Mycobacterium Contamination of a Mammalian Cell Bioreactor ProcessThe authors present a case study identifying a contaminant.
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Efficient Multiproduct Process Development Case StudyAchieving multiproduct development within shortened timelines.
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Designing a Biomanufacturing Facility Incorporating Single-Use TechnologiesAsking the right questions is crucial to establishing a biopharmaceutical facility design.
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Designing a Control Strategy for Facilities with Single-Use SystemsEarly control architecture decisions can impact a facility’s long-term growth, flexibility, and efficiency.
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Qualification and Validation of Single-Use Shipping SystemsThe authors provide their perspectives on shipping validation.
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An Integrated Approach to Shipping Liquid in Single-Use SystemsIncreased use of single-use systems has led to a need to redefine safe, stable and integral systems for shipping biopharmaceuticals around the world. This article provides qualification data under international ASTM D4169 norms.
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Qualification and Validation of Single-Use Shipping SystemsThe authors provide their perspectives on shipping validation.
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Forced Degradation Studies for BiopharmaceuticalsThe author addresses critical issues to consider prior to performing forced degradation studies and provides best practice recommendations for these types of studies.
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A Platform Approach for the Identity Testing of Multi-Component Cell-Culture MediaData acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
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A Platform Approach for the Identity Testing of Multi-Component Cell-Culture MediaData acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
Latest:
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture MediaData acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
Latest:
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture MediaData acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
