Single-Stage Clarification

The 3M Harvest RC clarifier from 3M Health Care uses a proprietary fibrous chromatography media to condense three process steps into a single-stage purification of recombinant protein therapeutics.

The clarifier provides monoclonal antibody recovery of more than 95% and can be used with cultures with different cell densities, high-packed cell volumes, and cell culture characteristics. The quaternary ammonium functionalized polypropylene fiber, and 0.2 µm PES membrane, provides scalable clarification from discovery to commercial manufacturing scale.

The clarifier introduces chromatographic separation earlier in the process to remove soluble impurities, resulting in cleaner effluent, the company reports.

3M Health Care

www.3m.com/harvest