BioPharm International-03-02-2009
Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
Benedicte Lebreton;Amber R. Cothran;Sandy Sargis;Melody Trexler-Schmidt;Binh Q. Thai;Brian Kelley;Gregory S. Blank;Stefanie Sze-Khoo
March 2nd 2009ArticleArticle
Altering the order of operations, using new resins, and increasing dynamic binding capacity can obviate the need for major facilty changes.
The Development and Application of a Monoclonal Antibody Purification Platform
Paul Johnson;Judy Glynn;Kristin Thomas;Natarajan Ramasubramanyan, PhD;Paul Mensah, PhD;Timothy Hagerty;Gopinath Annathur;Timothy Pabst, PhD
March 2nd 2009ArticleArticle
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
Advances in Non-Protein A Purification Processes for Human Monoclonal Antibodies
March 2nd 2009ArticleArticle
In three non-affinity purification processes based on cation exchange capture with high binding capacity, applying a host cell protein exclusion strategy enabled robust scale up and better economics.
