Uwe Gottschalk, PhD

As constant scale up grows out of favor in the biopharmaceutical industry, new-and old-approaches are required. The author reviews the state of downstream processing and considers potential solutions, including the streamlining of full processes and borrowed technologies

Uwe Gottschalk, vice-president of purification technologies, Sartorius Stedim Biotech, discusses specific challenges in protein purification.

The industry needs to embrace innovation to improve the efficiency and robustness of biopharmaceutical purification without driving up the cost of goods.

The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies.

This summary provides an introduction to our special issue on Separation and Purification.

An analysis of flow rate, load density, viral clearance, and cost.

A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process.

STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps.

Results from a process developed for a commercial antibody.

To achieve the right balance between disposable and reuseable options, companies must consider important technical and economic factors.