Novartis Licenses AVEO Oncology’s Antibody to Treat Metabolic Syndrome
Novartis will develop AVEO’s AV-380, an investigational humanized antibody targeting growth differentiation factor 15.
Novartis will develop AVEO Oncology’s first-in-class humanized antibody targeting growth differentiation factor 15 (GDF15), a proinflammatory cytokine. According to a press release from AVEO, AVEO could stand to earn up to $326 million for the deal, which includes a $15-million upfront payment and milestone payments of up to $311 million.
The antibody will be developed and investigated for its efficacy in treating wasting syndrome (e.g., weight and muscle loss), which is typically associated with chronic diseases such as cancer, chronic kidney disease, congestive heart failure, and chronic obstructive pulmonary disease. The metabolic condition, commonly known as Cachexia, is also associated with the clinical manifestation of anemia, inflammation, and suppression of immune functions.
Novartis will retain rights to all products and derivative products through the partnership and will be responsible for the commercialization and manufacturing of the medication and associated products.
Source: AVEO
EMA Recommends Imfinzi-Based Perioperative Regimen for Treating Resectable NSCLC
March 10th 2025The committee’s recommendation is based on results from a Phase III trial in which Imfinzi demonstrated a reduced risk of recurrence, progression, or death by 32% compared to neoadjuvant chemotherapy alone.
International Women’s Day 2025: A Promising Future for Gender Diversity in Pharma
March 8th 2025In an interview with BioPharm International®, Sheryl Johnson from Orbia Fluor & Energy Materials chats about gender diversity, how women are helping to advance innovation, sustainability challenges, and progress in the field of inhaled drugs.
