Featured Resources for Oligonucleotides Separations
Fundamentals of Oligonucleotide Separation by HPLC
From siRNA to mRNA to DNA, separating full-length product from impurities can be challenging. Depending on the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use to characterize or purify your molecule.
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Evaluation of New High pH Stable, Superficially-porous Particle Columns for the Reversed-phase Separation of Oligonucleotides
In this work, we evaluate the uses of new high pH stable, superficially-porous particles for oligo separations for fast and high resolution analysis, and compare them with totally porous particles.
High Performance DNA Oligonucleotide Purification Using Agilent TOP-DNA
Trityl-on purification enhances the selectivity between the full-length sequence and the truncated failures. Solid phase extraction (SPE) tubes provide a low-cost method for this type of purification. Read about how Agilent TOP-DNA cartridges make it easy to quickly obtain outstanding yields of high-purity synthetic DNA oligonucleotides.
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Fast and High-Resolution Reversed-Phase Separation of Synthetic Oligonucleotides
In this application note, we demonstrate fast and high-resolution separation and identification of a number of de-protected (removal of the dimethoxytrityl group (DMT)) DNA and RNA oligonucleotides, using Agilent AdvanceBio Oligonucleotide columns.
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High Resolution Separations of Oligonucleotides Using PL-SAX Strong Anion-Exchange HPLC Columns
In this application note, you can learn how to obtain fast and high-resolution separations and identifications of de-protected DNA and RNA oligonucleotides to ensure High-purity products.
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Direct Analysis of In-Process Oligonucleotides Without Manual Purification
Learn about direct 2D-LC analysis of oligonucleotides in solution with high salt content and online desalting performed in the first dimension (1D), followed by IP-RPLC analysis in the second dimension (2D) in this application note.
Construction Efficiency with The floorlessPOD: A G-CON Prefabricated Cleanroom Solution
March 7th 2025G-CON’s floorlessPOD is a free-standing structure that provides direct integration with the host facility floor, eliminating the need for ramps, platforms and stairs typically required with prefabricated structures that have integrated floors. With fully integrated MEP, the floorlessPOD is an ideal solution when the cleanroom cannot be structurally supported by the host facility.
G-CON: The Benefits of G-CON Service Solutions
February 19th 2025Following project close out, the G-CON Service Team will ensure that your PODs continue to function as intended. Service offerings include preventative maintenance plans, spare parts, NEBB certified TAB services (testing, adjusting, and balancing), and expedited support options. Additionally, the Service Team handles all warranty requests and manages data from these activities to drive continuous improvement in our products’ performance across all aspects.
Cleanroom Doors: Tailored Solutions for Seamless Integration and Compliance
February 19th 2025Learn about the customization of cleanroom doors to meet specific operational and design requirements. This paper highlights GCS's ability to tailor door solutions, ensuring seamless integration with existing cleanroom infrastructure while maintaining efficiency, sterility, and compliance with industry standards. With a commitment to quality, compliance, and efficiency, GCS delivers door solutions designed to enhance cleanroom performance and meet the stringent demands of controlled environments.
