Direct LC-MS Characterization of Glycoform Distribution and Low Molecular Weight Impurities in mAb Process
Using the BioAccord LC-MS System and an Ambr® 15, we developed an analytical method for rapid mAb glycoform confirmations and mAb purity assessments. This unique method is high throughput capable and has the potential to be a fully automated platform for mid-process intraday monitoring of CQAs.
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New Strategies for a Better Glycosylation Profile
January 22nd 2025Article
Glycan analysis provides key information on critical quality attributes that could affect stability, safety and efficacy of a protein therapeutic. Specific needs for understanding the glycosylation profiles change throughout the drug development process, but the requirement for high-resolution glycan information remains the same and is essential to help ensure product quality.
