BioPharm International
November 02, 2007
Articles
2007 Supplement
6
A solution for the problems of a "bag in a can" system would be a fully jacketed and insulated container, similar to a traditional freeze tank.
November 02, 2007
Articles
2007 Supplement
6
One of the challenges of adopting single-use technology is that not all cell lines are compatible with disposable bioreactors.
November 02, 2007
Articles
2007 Supplement
6
Disposables are increasingly being used in the manufacture of biopharmaceuticals. This article describes the design of a fully disposable process for the cGMP manufacture of clinical trial grade plasmid DNA. It addresses the rationale for implementing such a process with respect to the manufacture of patient-specific plasmid DNA vaccines for the treatment of leukemia. The process incorporates a number of disposable technologies, which are simple to use and thus reduce the need for investment in expensive equipment and cleaning validation.
November 02, 2007
Articles
2007 Supplement
6
Comparison of the integrated assembly purified MGG to the control revealed that the purity if the MGG was very high.
November 02, 2007
Articles
2007 Supplement
6
Single-use systems reduce maintenance and capital expense by eliminating expensive vessels, valves, and sanitary piping assemblies.