BioPharm International
August 02, 2010
Issue PDF
2010 Supplement
6
Structure, Comparability, and Biosimilars: Advances in Protein Characterization
August 02, 2010
Peer-Reviewed Research
2010 Supplement
6
By providing information on the relative accessibility of locations within a protein, HDX by mass spectrometry opens new windows into the higher order structure of biomolecules.
August 02, 2010
Peer-Reviewed Research
2010 Supplement
6
Biomanufacturers should follow a risk-based approach to decide which methods to use to characterize their products.
August 02, 2010
Peer-Reviewed Research
2010 Supplement
6
Spectroscopic methods such as circular dichroism can detect subtle differences in higher order structure before and after changes in process and formulation.
August 02, 2010
Peer-Reviewed Research
2010 Supplement
6
Simple methods can characterize polysaccharide vaccines and recombinant cytokines at high resolution.
August 02, 2010
Peer-Reviewed Research
2010 Supplement
6
Intact protein LC–MS detected a mass variance of 62 Da and peptide mapping located a difference of two amino acids.